picrotoxin

URI: https://gptkb.org/entity/picrotoxin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:Dragon gptkb:chemical_compound plant toxin
gptkbp:antidote	gptkb:barbiturate_poisoning_(experimental)
gptkbp:appearance	colorless, bitter crystals
gptkbp:CASNumber	124-87-8
gptkbp:category	gptkb:GABA_antagonist plant toxin convulsant
gptkbp:chemicalFormula	C15H16O6
gptkbp:effect	induces seizures stimulates respiration
gptkbp:foundIn	gptkb:Anamirta_cocculus
https://www.w3.org/2000/01/rdf-schema#label	picrotoxin
gptkbp:IUPACName	(3aR,6aS,6bR,8aS,9aS,13aR,13bR)-1,5,5,8a,9a,13a-hexahydro-3a,6a,13b-trimethyl-2,4-dioxo-3,3a,4,5,6,6a,6b,7,8,8a,9,9a,13,13a,13b-pentadecahydro-1H-cyclopenta[a]phenanthrene-7,13-diol
gptkbp:KEGGID	C07580
gptkbp:LD50	5 mg/kg (mouse, i.p.)
gptkbp:mechanismOfAction	GABA_A receptor antagonist
gptkbp:meltingPoint	200–205 °C
gptkbp:molecularWeight	308.29 g/mol
gptkbp:PubChem_CID	gptkb:CHEBI:31970 gptkb:DB13162 gptkb:CHEMBL418 10251
gptkbp:solubility	slightly soluble in water soluble in ether soluble in alcohol
gptkbp:source	gptkb:seeds_of_Anamirta_cocculus
gptkbp:toxicity	convulsant
gptkbp:UNII	8ZV102C6OH
gptkbp:uses	experimental pharmacology
gptkbp:bfsParent	gptkb:4-aminobutanoic_acid gptkb:GABA_A_receptor gptkb:GABA_C_receptor
gptkbp:bfsLayer	6