|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Fas-Associated_protein_with_Death_Domain
gptkb:MORT1
|
|
gptkbp:alternativeName
|
gptkb:Fas-Associated_protein_with_Death_Domain
gptkb:MORT1
|
|
gptkbp:associatedWith
|
gptkb:cancer
apoptosis
immune response
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
Fas-associated death domain protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000168040
8772
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
adaptor molecule in death receptor pathways
mediates apoptotic signaling
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0006915 (apoptotic process)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:3573
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FADD gene
|
|
gptkbp:interactsWith
|
gptkb:Fas_receptor
gptkb:TRADD
gptkb:Caspase-8
gptkb:RIPK1
|
|
gptkbp:involvedIn
|
gptkb:Fas_signaling_pathway
TNF receptor signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q13.3
chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
can affect apoptosis regulation
can lead to immune disorders
|
|
gptkbp:OMIM
|
602457
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Fadd
rat Fadd
|
|
gptkbp:pathway
|
KEGG: hsa04210 (apoptosis)
KEGG: hsa04660 (T cell receptor signaling pathway)
|
|
gptkbp:PDB
|
1E41
|
|
gptkbp:product
|
gptkb:FADD
|
|
gptkbp:proteinFamily
|
gptkb:death_effector_domain
death domain
|
|
gptkbp:regulates
|
phosphorylation
post-translational modifications
|
|
gptkbp:significance
|
implicated in cancer progression
implicated in autoimmune diseases
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:UniProtID
|
gptkb:Q13158
|
|
gptkbp:bfsParent
|
gptkb:FADD
|
|
gptkbp:bfsLayer
|
7
|