Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:containsGene |
gptkb:TNFRSF10B
gptkb:TNFRSF10A gptkb:TNFRSF10D TNFRSF10C TNFSF10 |
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
induces apoptosis in cancer cells
regulates immune response |
| https://www.w3.org/2000/01/rdf-schema#label |
TRAIL signaling pathway
|
| gptkbp:involves |
gptkb:caspase-8
gptkb:caspase-3 gptkb:death-inducing_signaling_complex_(DISC) gptkb:NF-κB_pathway apoptosis cell death caspase activation cytochrome c release Bax protein activation of caspase-9 Bid protein FADD (Fas-associated death domain protein) TRAIL (TNF-related apoptosis-inducing ligand) TRAIL receptors TRAIL-R1 (DR4) TRAIL-R2 (DR5) cellular FLICE-inhibitory protein (c-FLIP) decoy receptors (DcR1, DcR2) mitochondrial pathway |
| gptkbp:relatedTo |
tumor suppression
cancer therapy research |
| gptkbp:bfsParent |
gptkb:FADD
|
| gptkbp:bfsLayer |
7
|