|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Weaver_syndrome
leukemia
prostate cancer
B-cell lymphoma
myeloid malignancies
|
|
gptkbp:catalyzes
|
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:encodedBy
|
gptkb:EZH2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2146
|
|
gptkbp:enzymeCommissionNumber
|
2.1.1.43
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:gene
|
gptkb:EZH2
|
|
gptkbp:HGNC_ID
|
3527
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EZH2 (in humans)
|
|
gptkbp:inhibitedBy
|
gptkb:miR-101
gptkb:miR-214
gptkb:miR-26a
|
|
gptkbp:interactsWith
|
gptkb:EED
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic
|
|
gptkbp:OMIM
|
601573
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:overexpressedIn
|
cancer cells
|
|
gptkbp:PDB
|
gptkb:6C23
gptkb:5HYN
5IJ7
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_004447.2
|
|
gptkbp:regulates
|
apoptosis
differentiation
gene expression
cell cycle
|
|
gptkbp:role
|
gptkb:X-chromosome_inactivation
cell proliferation
development
stem cell maintenance
epigenetic gene silencing
tumor progression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
gptkb:EPZ-6438
gptkb:GSK126
gptkb:tazemetostat
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:E(z)_protein
|
|
gptkbp:bfsLayer
|
8
|