DNA-dependent protein kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	requires DNA ends
gptkbp:alsoKnownAs	gptkb:DNA-PK
gptkbp:component	gptkb:DNA-PKcs Ku70/Ku80 heterodimer
gptkbp:discoveredBy	gptkb:David_J._Chen
gptkbp:discoveredIn	1990
gptkbp:EC_number	2.7.11.1
gptkbp:enzymeClassification	serine/threonine protein kinase
gptkbp:function	gptkb:non-homologous_end_joining DNA double-strand break repair
gptkbp:gene	gptkb:PRKDC
gptkbp:GO_term	gptkb:GO:0004674
gptkbp:inhibitedBy	gptkb:NU7441 gptkb:wortmannin
gptkbp:locale	gptkb:nucleus
gptkbp:molecularWeight	~469 kDa (DNA-PKcs)
gptkbp:organism	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:PDB	5LUQ
gptkbp:phosphorylates	gptkb:H2AX gptkb:p53 XRCC4
gptkbp:regulates	autophosphorylation
gptkbp:relatedTo	gptkb:ATM_kinase gptkb:ATR_kinase
gptkbp:requires	gptkb:V(D)J_recombination
gptkbp:role	gptkb:cancer gptkb:immunodeficiency
gptkbp:UniProtID	gptkb:P78527
gptkbp:bfsParent	gptkb:DNA-PK
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	DNA-dependent protein kinase