DNA-dependent protein kinase

URI: https://gptkb.org/entity/DNA-dependent_protein_kinase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy requires DNA ends
gptkbp:alsoKnownAs gptkb:DNA-PK
gptkbp:component gptkb:DNA-PKcs
Ku70/Ku80 heterodimer
gptkbp:discoveredBy gptkb:David_J._Chen
gptkbp:discoveredIn 1990
gptkbp:EC_number 2.7.11.1
gptkbp:enzymeClassification serine/threonine protein kinase
gptkbp:function gptkb:non-homologous_end_joining
DNA double-strand break repair
gptkbp:gene gptkb:PRKDC
gptkbp:GO_term gptkb:GO:0004674
https://www.w3.org/2000/01/rdf-schema#label DNA-dependent protein kinase
gptkbp:inhibitedBy gptkb:NU7441
gptkb:wortmannin
gptkbp:locale gptkb:nucleus
gptkbp:molecularWeight ~469 kDa (DNA-PKcs)
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:PDB 5LUQ
gptkbp:phosphorylates gptkb:H2AX
gptkb:p53
XRCC4
gptkbp:regulates autophosphorylation
gptkbp:relatedTo gptkb:ATM_kinase
gptkb:ATR_kinase
gptkbp:requires gptkb:V(D)J_recombination
gptkbp:role gptkb:cancer
immunodeficiency
gptkbp:UniProtID gptkb:P78527
gptkbp:bfsParent gptkb:DNA-PK
gptkbp:bfsLayer 6