Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:H2_AX
gptkb:checkpoint_kinase_2 |
| gptkbp:associated_with |
cancer therapy
cell cycle regulation tumorigenesis replication stress checkpoint signaling |
| gptkbp:established |
VE-821
single-stranded DNA CC T241533 ATR inhibitors replication fork stalling |
| gptkbp:form |
ATR-1
ATR-2 |
| gptkbp:function |
DNA damage response
|
| gptkbp:has_role |
DNA repair
apoptosis regulation cellular response to stress cellular senescence |
| https://www.w3.org/2000/01/rdf-schema#label |
ATR kinase
|
| gptkbp:interacts_with |
gptkb:ATM_protein
p53 protein BRC A1 protein |
| gptkbp:is_aimed_at |
cancer therapies
|
| gptkbp:is_associated_with |
therapeutic resistance
chemo-resistance radio-resistance |
| gptkbp:is_essential_for |
cell viability under stress
|
| gptkbp:is_involved_in |
DNA replication
cellular homeostasis immune response DNA repair mechanisms tumor suppression cellular differentiation cellular signaling pathways |
| gptkbp:is_part_of |
DNA damage checkpoint pathway
cell cycle checkpoint pathway |
| gptkbp:is_represented_in |
various tissues
cancer cells |
| gptkbp:is_studied_in |
cancer research
pharmacology research cellular biology research genomic stability research |
| gptkbp:location |
gptkb:physicist
|
| gptkbp:material |
gptkb:p53
Chk1 BRC A1 MC M2-7 complex |
| gptkbp:promoter |
gptkb:ATR
|
| gptkbp:regulates |
gptkb:ATM_kinase
Chk1 kinase Chk2 kinase |
| gptkbp:weight |
approximately 300 k Da
|