Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
single-stranded DNA
replication stress |
| gptkbp:associatedWith |
gptkb:cancer
genomic instability |
| gptkbp:biologicalProcess |
serine/threonine kinase activity
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:EC_number |
2.7.11.1
|
| gptkbp:encodedBy |
ATR gene
|
| gptkbp:fullName |
ataxia telangiectasia and Rad3 related protein
|
| gptkbp:function |
DNA damage response
cell cycle checkpoint regulation phosphorylation of target proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
ATR kinase
|
| gptkbp:inhibitedBy |
cell cycle progression
AZD6738 Berzosertib VE-821 |
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:mutationAssociatedWith |
Seckel syndrome
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:phosphorylates |
gptkb:H2AX
gptkb:BRCA1 gptkb:p53 CHK1 |
| gptkbp:relatedTo |
gptkb:ATM_kinase
gptkb:DNA-PKcs |
| gptkbp:requires |
embryonic development
|
| gptkbp:UniProtID |
Q13535
|
| gptkbp:bfsParent |
gptkb:AATF
|
| gptkbp:bfsLayer |
6
|