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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
DNA-dependent protein kinase holoenzyme
|
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gptkbp:component
|
gptkb:DNA-PKcs
gptkb:Ku70
gptkb:Ku80
|
|
gptkbp:discoveredBy
|
gptkb:David_J._Chen
|
|
gptkbp:EC_number
|
2.7.11.1
|
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gptkbp:enzyme
|
serine/threonine protein kinase
|
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gptkbp:foundIn
|
gptkb:nucleus
|
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gptkbp:function
|
gptkb:non-homologous_end_joining
DNA double-strand break repair
|
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gptkbp:gene_associated
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gptkb:PRKDC
gptkb:XRCC5
gptkb:XRCC6
|
|
gptkbp:GO_term
|
gptkb:GO:0003684
GO:0006974
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA-PK holoenzyme
|
|
gptkbp:inhibitedBy
|
gptkb:NU7441
gptkb:wortmannin
|
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gptkbp:involvedIn
|
gptkb:V(D)J_recombination
|
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gptkbp:molecularWeight
|
~469 kDa (DNA-PKcs subunit)
~70 kDa (Ku70 subunit)
~80 kDa (Ku80 subunit)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
5Y3R
|
|
gptkbp:phosphorylates
|
gptkb:Artemis
gptkb:H2AX
gptkb:p53
XRCC4
|
|
gptkbp:relatedTo
|
immunodeficiency
cancer therapy resistance
|
|
gptkbp:UniProtID
|
P12956 (Ku70)
P13010 (Ku80)
P78527 (DNA-PKcs)
|
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gptkbp:bfsParent
|
gptkb:DNA-PK
|
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gptkbp:bfsLayer
|
6
|