|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
KU70
X-ray repair cross-complementing protein 6
|
|
gptkbp:associatedWith
|
gptkb:immunodeficiency
cancer susceptibility
genomic stability
|
|
gptkbp:biologicalProcess
|
regulation of transcription
apoptotic process
cellular response to DNA damage stimulus
chromosome organization
double-strand break repair via nonhomologous end joining
regulation of telomere maintenance
|
|
gptkbp:discoveredBy
|
X-ray repair cross-complementation group
|
|
gptkbp:encodes
|
Ku70 protein
|
|
gptkbp:Entrez_Gene_ID
|
2547
ENSG00000196419
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:form
|
Ku heterodimer
|
|
gptkbp:formsComplexWith
|
gptkb:XRCC5
|
|
gptkbp:function
|
DNA repair
DNA binding
protein heterodimerization activity
DNA end binding
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
12858
|
|
gptkbp:interactsWith
|
gptkb:DNA-PKcs
gptkb:XRCC5
LIG4
XRCC4
|
|
gptkbp:involvedIn
|
DNA double-strand break repair
|
|
gptkbp:length
|
609 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q13.1
chromosome 22
|
|
gptkbp:location
|
gptkb:nucleus
chromatin
nucleoplasm
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased sensitivity to ionizing radiation
|
|
gptkbp:OMIM
|
152942
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Xrcc6
|
|
gptkbp:orthologInYeast
|
YKU70
|
|
gptkbp:participatedIn
|
gptkb:non-homologous_end_joining
|
|
gptkbp:pathway
|
gptkb:V(D)J_recombination
DNA damage response
|
|
gptkbp:RefSeq
|
NM_001469
|
|
gptkbp:UniProtID
|
P12956
|
|
gptkbp:bfsParent
|
gptkb:DNA-PK
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
XRCC6
|