Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
KU70
X-ray repair cross-complementing protein 6 |
| gptkbp:associatedWith |
immunodeficiency
cancer susceptibility genomic stability |
| gptkbp:biologicalProcess |
regulation of transcription
apoptotic process cellular response to DNA damage stimulus chromosome organization double-strand break repair via nonhomologous end joining regulation of telomere maintenance |
| gptkbp:discoveredBy |
X-ray repair cross-complementation group
|
| gptkbp:encodes |
Ku70 protein
|
| gptkbp:Entrez_Gene_ID |
2547
ENSG00000196419 |
| gptkbp:expressedIn |
gptkb:nucleus
|
| gptkbp:form |
Ku heterodimer
|
| gptkbp:formsComplexWith |
gptkb:XRCC5
|
| gptkbp:function |
DNA repair
DNA binding protein heterodimerization activity DNA end binding |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
12858
|
| https://www.w3.org/2000/01/rdf-schema#label |
XRCC6
|
| gptkbp:interactsWith |
gptkb:DNA-PKcs
gptkb:XRCC5 LIG4 XRCC4 |
| gptkbp:involvedIn |
DNA double-strand break repair
|
| gptkbp:length |
609 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:22q13.1
chromosome 22 |
| gptkbp:location |
gptkb:nucleus
chromatin nucleoplasm |
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:mutationAssociatedWith |
increased sensitivity to ionizing radiation
|
| gptkbp:OMIM |
152942
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Xrcc6
|
| gptkbp:orthologInYeast |
YKU70
|
| gptkbp:participatedIn |
gptkb:non-homologous_end_joining
|
| gptkbp:pathway |
gptkb:V(D)J_recombination
DNA damage response |
| gptkbp:RefSeq |
NM_001469
|
| gptkbp:UniProtID |
P12956
|
| gptkbp:bfsParent |
gptkb:DNA-PK
|
| gptkbp:bfsLayer |
6
|