Cytochrome P450 family 3 subfamily A member 4

URI: https://gptkb.org/entity/Cytochrome_P450_family_3_subfamily_A_member_4
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:CYP3A4
P450-3A
cytochrome P450 3A4
gptkbp:biologicalProcess monooxygenase activity
gptkbp:discoveredBy 1980s
gptkbp:EC_number 1.14.14.1
gptkbp:encodedBy gptkb:CYP3A4_gene
gptkbp:Entrez_Gene_ID GC03M123456
gptkbp:expressedIn liver
intestine
gptkbp:family gptkb:Cytochrome_P450
gptkbp:function drug metabolism
steroid metabolism
xenobiotic metabolism
gptkbp:HGNC_ID 2623
https://www.w3.org/2000/01/rdf-schema#label Cytochrome P450 family 3 subfamily A member 4
gptkbp:inducedBy gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
gptkbp:inhibitedBy gptkb:milk
gptkb:ketoconazole
gptkbp:locatedIn gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome 7q22.1
gptkbp:member 4
gptkbp:OMIM 124010
gptkbp:organism gptkb:Homo_sapiens
gptkbp:pathway drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
gptkbp:product gptkb:CYP3A4
gptkbp:RefSeq NM_017460
gptkbp:significance pharmacogenomics
drug-drug interactions
gptkbp:subfamily 3A
gptkbp:substrate gptkb:cyclosporine
gptkb:erythromycin
gptkb:midazolam
statins
testosterone
gptkbp:UniProtID P08684
gptkbp:bfsParent gptkb:P08641
gptkbp:bfsLayer 7