Statements (36)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:actsOn |
gptkb:cAMP
gptkb:cGMP |
| gptkbp:associatedWith |
gptkb:depression
asthma cardiovascular diseases inflammatory diseases erectile dysfunction |
| gptkbp:catalyzes |
hydrolysis of cyclic nucleotides
|
| gptkbp:discoveredIn |
1950s
|
| gptkbp:EC_number |
3.1.4.17
|
| gptkbp:familyMember |
gptkb:PDE1
gptkb:PDE10 gptkb:PDE11 gptkb:PDE2 gptkb:PDE3 gptkb:PDE4 gptkb:PDE5 gptkb:PDE6 gptkb:PDE7 gptkb:PDE8 gptkb:PDE9 |
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:importantFor |
signal transduction
regulation of intracellular levels of cAMP and cGMP |
| gptkbp:inhibitedBy |
gptkb:theophylline
gptkb:sildenafil gptkb:milrinone gptkb:rolipram caffeine |
| gptkbp:regulates |
cellular signaling pathways
|
| gptkbp:target |
phosphodiesterase inhibitors
|
| gptkbp:bfsParent |
gptkb:CPD
|
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cyclic Phosphodiesterase
|