Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
gptkb:benign_prostatic_hyperplasia
erectile dysfunction pulmonary arterial hypertension |
| gptkbp:cofactor |
Mg2+
Zn2+ |
| gptkbp:discoveredBy |
1990s
|
| gptkbp:EC_number |
3.1.4.17
|
| gptkbp:fullName |
gptkb:phosphodiesterase_type_5
|
| gptkbp:function |
hydrolyzes cGMP
|
| gptkbp:gene |
PDE5A
|
| https://www.w3.org/2000/01/rdf-schema#label |
PDE5
|
| gptkbp:inhibitedBy |
gptkb:vardenafil
gptkb:avanafil gptkb:sildenafil gptkb:tadalafil increases cGMP levels promotes vasodilation |
| gptkbp:locatedOnChromosome |
chromosome 4 (PDE5A gene in humans)
|
| gptkbp:location |
platelets
smooth muscle vascular tissue corpus cavernosum |
| gptkbp:product |
gptkb:GMP
|
| gptkbp:role |
regulates blood flow
regulates smooth muscle contraction |
| gptkbp:significance |
target for erectile dysfunction drugs
target for pulmonary hypertension drugs |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
gptkb:cGMP
|
| gptkbp:bfsParent |
gptkb:Cyclic_Phosphodiesterase
|
| gptkbp:bfsLayer |
6
|