Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
schizophrenia neurological disorders |
| gptkbp:EC_number |
3.1.4.54
|
| gptkbp:expressedIn |
gptkb:kidney
brain heart liver |
| gptkbp:foundIn |
gptkb:human
gptkb:mouse right |
| gptkbp:fullName |
phosphodiesterase 9
|
| gptkbp:function |
hydrolyzes cGMP
|
| gptkbp:gene |
PDE9A
|
| https://www.w3.org/2000/01/rdf-schema#label |
PDE9
|
| gptkbp:inhibitedBy |
BAY 73-6691
PF-04447943 |
| gptkbp:locatedOnChromosome |
gptkb:human_chromosome_21
|
| gptkbp:molecularWeight |
~117 kDa
|
| gptkbp:notSubstrate |
gptkb:cAMP
|
| gptkbp:orthologIn |
mouse PDE9A
rat PDE9A |
| gptkbp:regulates |
regulated by phosphorylation
|
| gptkbp:relatedTo |
cGMP signaling
|
| gptkbp:structure |
contains catalytic domain
contains GAF domain |
| gptkbp:substrate |
gptkb:cGMP
|
| gptkbp:UniProtID |
O76083
|
| gptkbp:bfsParent |
gptkb:Cyclic_Phosphodiesterase
|
| gptkbp:bfsLayer |
6
|