|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
drug metabolism
steroid metabolism
xenobiotic metabolism
|
|
gptkbp:hasPolymorphism
|
CYP3A5*3
CYP3A4*22
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP3A enzymes
|
|
gptkbp:includes
|
gptkb:CYP3A5
gptkb:CYP3A4
gptkb:CYP3A43
gptkb:CYP3A7
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:ketoconazole
|
|
gptkbp:locatedOnChromosome
|
chromosome 7q21-q22
|
|
gptkbp:location
|
gptkb:cancer
gptkb:kidney
liver
intestine
|
|
gptkbp:metabolism
|
gptkb:cyclosporine
gptkb:lidocaine
gptkb:clarithromycin
gptkb:tamoxifen
gptkb:erythromycin
gptkb:verapamil
gptkb:midazolam
quinidine
statins
ethinylestradiol
fentanyl
diltiazem
docetaxel
paclitaxel
alprazolam
testosterone
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:percentageOfDrugMetabolism
|
~50% of clinically used drugs
|
|
gptkbp:proteinFamily
|
gptkb:CYP3A
|
|
gptkbp:regulates
|
gptkb:constitutive_androstane_receptor
gptkb:pregnane_X_receptor
|
|
gptkbp:significance
|
pharmacogenomics
drug-drug interactions
|
|
gptkbp:subclassOf
|
gptkb:cytochrome_P450_enzymes
|
|
gptkbp:bfsParent
|
gptkb:CYP3A
|
|
gptkbp:bfsLayer
|
6
|