|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP2A
gptkb:P450C2A
gptkb:cytochrome_P450,_family_2,_subfamily_A,_polypeptide_6
coumarin 7-hydroxylase
|
|
gptkbp:associatedWith
|
nicotine dependence
smoking behavior
drug metabolism variability
|
|
gptkbp:encodes
|
gptkb:cytochrome_P450_2A6
|
|
gptkbp:Entrez_Gene_ID
|
1548
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
gptkb:cancer
liver
nasal mucosa
|
|
gptkbp:function
|
monooxygenase activity
drug metabolism
coumarin 7-hydroxylation
nicotine metabolism
xenobiotic metabolism
|
|
gptkbp:hasPolymorphism
|
gptkb:CYP2A6*2_(inactive_variant)
gptkb:CYP2A6*4_(gene_deletion)
CYP2A6*9 (reduced activity)
|
|
gptkbp:HGNC_ID
|
2597
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP2A6 (human)
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:methoxsalen
gptkb:pilocarpine
gptkb:tranylcypromine
gptkb:selegiline
gptkb:letrozole
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
19q13.2
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:OMIM
|
601040
|
|
gptkbp:orthologIn
|
Cyp2a5 (mouse)
|
|
gptkbp:referenceGenome
|
NM_000762
|
|
gptkbp:referenceProtein
|
NP_000753
|
|
gptkbp:substrate
|
gptkb:valproic_acid
gptkb:aflatoxin_B1
gptkb:tegafur
gptkb:letrozole
nicotine
coumarin
aromatic amines
|
|
gptkbp:UniProtID
|
P11509
|
|
gptkbp:bfsParent
|
gptkb:Cyp2a5
|
|
gptkbp:bfsLayer
|
7
|