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gptkbp:instanceOf
|
genome editing technology
prokaryotic immune system
|
|
gptkbp:alternativeTo
|
gptkb:TALEN
gptkb:ZFN
meganucleases
|
|
gptkbp:application
|
gptkb:biotechnology
gptkb:medicine
agriculture
gene therapy
disease modeling
functional genomics
|
|
gptkbp:component
|
gptkb:CRISPR
gptkb:guide_RNA
Cas protein
|
|
gptkbp:controversy
|
gptkb:intellectual_property
germline editing
off-target effects
designer babies
|
|
gptkbp:discoveredBy
|
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
gptkb:Francisco_Mojica
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRISPR-Cas
|
|
gptkbp:mechanismOfAction
|
targeted DNA cleavage
adaptive immunity
RNA-guided endonuclease activity
|
|
gptkbp:NobelPrizeYear
|
gptkb:2020_Nobel_Prize_in_Chemistry
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
|
|
gptkbp:notableVariant
|
gptkb:CRISPR-Cas12
gptkb:CRISPR-Cas13
gptkb:CRISPR-Cas9
|
|
gptkbp:patentDispute
|
gptkb:Broad_Institute
gptkb:University_of_California
|
|
gptkbp:regulates
|
gptkb:public_policy
bioethics
|
|
gptkbp:relatedTo
|
gptkb:CRISPR_array
gptkb:Cas12_protein
gptkb:Cas13_protein
gptkb:Cas9_protein
gptkb:crRNA
gptkb:tracrRNA
spacer sequence
protospacer adjacent motif (PAM)
|
|
gptkbp:usedFor
|
gene editing
genome engineering
gene activation
gene knockout
gene repression
|
|
gptkbp:bfsParent
|
gptkb:FnCas12a
|
|
gptkbp:bfsLayer
|
8
|