Statements (181)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
3
|
| gptkbp:bfsParent |
gptkb:Jennifer_Doudna
gptkb:CRISPR_Therapeutics |
| gptkbp:advocates_for |
gptkb:physicist
|
| gptkbp:allows |
ethical concerns
off-target effects targeted DNA modification regulatory challenges complex traits targeted modification of DNA multigenic diseases targeted gene modification |
| gptkbp:applies_to |
gptkb:hospital
gptkb:Company agriculture |
| gptkbp:based_on |
natural processes
bacterial immune system |
| gptkbp:can_be_used_with |
other gene editing technologies
|
| gptkbp:can_lead_to |
off-target effects
|
| gptkbp:composed_of |
Cas9 protein
CRISPR sequences CRISPRRNA (cr RNA) trans-activating CRISPRRNA (tracr RNA) |
| gptkbp:developed_by |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna |
| gptkbp:enables |
gene replacement
gene insertion gene knockout |
| gptkbp:features |
cutting DNA at specific locations
|
| gptkbp:first_introduced |
gptkb:2012
|
| gptkbp:future_plans |
treat genetic disorders
enhance crop resistance enhance crop resilience create gene drives treat genetic diseases |
| gptkbp:has_influence_on |
gptkb:item
personalized medicine |
| gptkbp:has_programs |
gptkb:hospital
gptkb:physicist gptkb:Company gptkb:item agriculture genetic disorders cancer research therapeutics vaccine development agricultural improvements |
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-Cas9
|
| gptkbp:invention |
gptkb:University_of_California
gptkb:Broad_Institute |
| gptkbp:investment |
ethical concerns
germline editing off-target effects |
| gptkbp:is_adopted_by |
pharmaceutical companies
biotech companies agricultural companies |
| gptkbp:is_associated_with |
gptkb:item
molecular biology public policy debates biological research agricultural innovation genetic engineering genetic modification ethical discussions genetic therapy |
| gptkbp:is_challenged_by |
ethical debates
scientific scrutiny |
| gptkbp:is_compared_to |
gptkb:Zinc_Finger_Nucleases
TALE Ns traditional gene editing methods |
| gptkbp:is_considered |
a game changer
a revolutionary tool a tool for precision medicine |
| gptkbp:is_considered_as |
revolutionary technology
|
| gptkbp:is_criticized_for |
safety concerns
ethical concerns lack of regulation bioethicists potential misuse |
| gptkbp:is_discussed_in |
gptkb:literary_work
|
| gptkbp:is_explored_in |
gptkb:healthcare_organization
crop yield improvement climate-resilient crops agricultural applications HIV treatment therapeutic applications environmental applications diabetes treatment agricultural improvements genetic disorders treatment sickle cell disease treatment muscular dystrophy treatment disease-resistant crops heart disease treatment cystic fibrosis treatment agricultural pest resistance infectious diseases treatment beta-thalassemia treatment hereditary blindness treatment neurodegenerative diseases treatment |
| gptkbp:is_featured_in |
gptkb:documentaries
|
| gptkbp:is_involved_in |
gene therapy research
synthetic biology research agricultural biotechnology research |
| gptkbp:is_part_of |
gptkb:item
molecular biology modern genetics genetic engineering genomics molecular biology techniques genome editing technologies genetic engineering toolkit the future of genetics |
| gptkbp:is_popular_in |
gptkb:Company
gptkb:Research_Institute universities biotechnology companies research institutions agricultural biotechnology |
| gptkbp:is_promoted_by |
educational workshops
online courses scientific conferences |
| gptkbp:is_recognized_by |
gptkb:Nobel_Prize_in_Chemistry
|
| gptkbp:is_studied_in |
gptkb:healthcare_organization
gptkb:cystic_fibrosis gptkb:sickle_cell_disease gptkb:DJ animal models clinical trials agricultural biotechnology HIV treatment plant models |
| gptkbp:is_subject_to |
patents
licensing agreements |
| gptkbp:is_supported_by |
gptkb:National_Science_Foundation
gptkb:Research_Institute advocacy groups scientific organizations various research institutions scientific funding |
| gptkbp:is_used_by |
biotechnology companies
research institutions biotech companies |
| gptkbp:is_used_for |
genome editing
|
| gptkbp:is_used_in |
gptkb:Person
gptkb:mythological_figure clinical trials plants |
| gptkbp:is_used_to |
study gene function
create genetically modified organisms develop disease models insert genes knock out genes modify gene expression enhance crop traits edit genomes create knockout models delete genes edit genes in embryos improve livestock genetics produce biopharmaceuticals |
| gptkbp:issues |
off-target effects
ethical implications |
| gptkbp:led_to |
new research fields
|
| gptkbp:origin |
gptkb:physicist
personalized medicine agricultural innovation bacterial immune system |
| gptkbp:produced_by |
gptkb:military_conflict
public interest |
| gptkbp:receives_funding_from |
government grants
private investments |
| gptkbp:regulates |
gptkb:FDA
gptkb:European_Medicines_Agency government agencies |
| gptkbp:requires |
guide RNA
|
| gptkbp:training |
university courses
|
| gptkbp:used_in |
agriculture
biomedical research genetic engineering |