Statements (180)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:biotechnology
|
| gptkbp:advocated_for |
gptkb:scientists
|
| gptkbp:allows |
targeted DNA modification
targeted modification of DNA targeted gene modification |
| gptkbp:based_on |
bacterial immune system
|
| gptkbp:can_be_combined_with |
other gene editing technologies
|
| gptkbp:can_be_used_in |
gptkb:animals
gptkb:humans plants |
| gptkbp:can_lead_to |
off-target effects
|
| gptkbp:composed_of |
Cas9 protein
CRISPR sequences CRISPR RNA (cr RNA) trans-activating CRISPR RNA (tracr RNA) |
| gptkbp:developed_by |
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna |
| gptkbp:enables |
gene replacement
gene insertion gene knockout |
| gptkbp:features_works_by |
cutting DNA at specific locations
|
| gptkbp:first_introduced |
gptkb:2012
|
| gptkbp:future_prospects |
treat genetic disorders
enhance crop resistance enhance crop resilience create gene drives treat genetic diseases |
| gptkbp:has_applications_in |
gptkb:gene_therapy
gptkb:biotechnology gptkb:Medicine agriculture genetic disorders cancer research therapeutics vaccine development agricultural improvements |
| gptkbp:has_influenced |
gptkb:biotechnology
personalized medicine |
| gptkbp:has_led_to |
new research fields
|
| gptkbp:has_limitations |
ethical concerns
off-target effects regulatory challenges complex traits multigenic diseases |
| gptkbp:has_produced |
gptkb:political_debates
public interest |
| https://www.w3.org/2000/01/rdf-schema#label |
CRISPR-Cas9
|
| gptkbp:invention |
gptkb:University_of_California
gptkb:Broad_Institute |
| gptkbp:investment |
ethical concerns
germline editing off-target effects |
| gptkbp:is_adopted_by |
pharmaceutical companies
biotech companies agricultural companies |
| gptkbp:is_applied_in |
gptkb:biotechnology
gptkb:Medicine agriculture |
| gptkbp:is_associated_with |
gptkb:biotechnology
molecular biology public policy debates biological research agricultural innovation genetic engineering genetic modification ethical discussions genetic therapy |
| gptkbp:is_based_on |
natural processes
bacterial immune system |
| gptkbp:is_challenged_by |
ethical debates
scientific scrutiny |
| gptkbp:is_compared_to |
gptkb:Zinc_Finger_Nucleases
TALENs traditional gene editing methods |
| gptkbp:is_considered |
a game changer
a revolutionary tool a tool for precision medicine |
| gptkbp:is_considered_as |
revolutionary technology
|
| gptkbp:is_criticized_for |
safety concerns
ethical concerns lack of regulation bioethicists potential misuse |
| gptkbp:is_discussed_in |
gptkb:literature
|
| gptkbp:is_explored_in |
gptkb:cancer_treatment
crop yield improvement climate-resilient crops agricultural applications HIV treatment therapeutic applications environmental applications diabetes treatment agricultural improvements genetic disorders treatment sickle cell disease treatment muscular dystrophy treatment disease-resistant crops heart disease treatment cystic fibrosis treatment agricultural pest resistance infectious diseases treatment beta-thalassemia treatment hereditary blindness treatment neurodegenerative diseases treatment |
| gptkbp:is_featured_in |
gptkb:documentaries
|
| gptkbp:is_funded_by |
government grants
private investments |
| gptkbp:is_involved_in |
gene therapy research
synthetic biology research agricultural biotechnology research |
| gptkbp:is_part_of |
gptkb:biotechnology
molecular biology modern genetics genetic engineering genomics molecular biology techniques genome editing technologies genetic engineering toolkit the future of genetics |
| gptkbp:is_popular_in |
gptkb:pharmaceuticals
gptkb:scientific_community universities biotechnology companies research institutions agricultural biotechnology |
| gptkbp:is_promoted_by |
educational workshops
online courses scientific conferences |
| gptkbp:is_recognized_by |
gptkb:Nobel_Prize_in_Chemistry
|
| gptkbp:is_regulated_by |
gptkb:FDA
gptkb:European_Medicines_Agency government agencies |
| gptkbp:is_studied_for |
gptkb:cancer_treatment
gptkb:cystic_fibrosis gptkb:sickle_cell_disease gptkb:muscular_dystrophy HIV treatment |
| gptkbp:is_studied_in |
animal models
clinical trials agricultural biotechnology plant models |
| gptkbp:is_subject_to |
patents
licensing agreements |
| gptkbp:is_supported_by |
gptkb:National_Science_Foundation
gptkb:National_Institutes_of_Health advocacy groups scientific organizations various research institutions scientific funding |
| gptkbp:is_taught_in |
university courses
|
| gptkbp:is_used_by |
biotechnology companies
research institutions biotech companies |
| gptkbp:is_used_in |
clinical trials
|
| gptkbp:is_used_to |
study gene function
create genetically modified organisms develop disease models insert genes knock out genes modify gene expression enhance crop traits edit genomes create knockout models delete genes edit genes in embryos improve livestock genetics produce biopharmaceuticals |
| gptkbp:issues |
off-target effects
ethical implications |
| gptkbp:originated_in |
gptkb:gene_therapy
personalized medicine agricultural innovation bacterial immune system |
| gptkbp:requires |
guide RNA
|
| gptkbp:used_for |
genome editing
|
| gptkbp:used_in |
agriculture
biomedical research genetic engineering |
| gptkbp:bfsParent |
gptkb:Jennifer_Doudna
|
| gptkbp:bfsLayer |
3
|