Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genome editing technology
|
| gptkbp:application |
gene therapy
functional genomics |
| gptkbp:composedOf |
FokI DNA-cleavage domain
zinc finger DNA-binding domain |
| gptkbp:contrastsWith |
gptkb:CRISPR-Cas9
gptkb:TALEN |
| gptkbp:developedBy |
gptkb:Dana_Carroll
gptkb:Sangamo_BioSciences |
| gptkbp:enables |
targeted double-strand breaks in DNA
|
| gptkbp:firstDescribed |
1996
|
| https://www.w3.org/2000/01/rdf-schema#label |
ZFN
|
| gptkbp:mechanismOfAction |
induces double-strand breaks at specific DNA sequences
|
| gptkbp:requires |
custom protein engineering
|
| gptkbp:standsFor |
gptkb:Zinc_Finger_Nuclease
|
| gptkbp:usedFor |
genome editing
gene knockout gene insertion |
| gptkbp:usedIn |
animal genome engineering
human cell genome engineering plant genome engineering |
| gptkbp:bfsParent |
gptkb:CRISPR
|
| gptkbp:bfsLayer |
5
|