|
gptkbp:instanceOf
|
biological pathway
genetic engineering technique
|
|
gptkbp:alternativeTo
|
gptkb:TALEN
gptkb:ZFN
|
|
gptkbp:awarded
|
gptkb:Nobel_Prize_in_Chemistry_2020
|
|
gptkbp:component
|
gptkb:Cas9_protein
gptkb:guide_RNA
|
|
gptkbp:controversy
|
ethical concerns in human germline editing
intellectual property disputes
|
|
gptkbp:discoveredBy
|
gptkb:Francisco_Mojica
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:enables
|
base editing
prime editing
gene silencing
epigenome editing
genetic screening
high-throughput screening
multiplexed gene editing
targeted DNA modification
|
|
gptkbp:firstDescribed
|
gptkb:Bacteria
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
|
|
gptkbp:fullName
|
gptkb:Clustered_Regularly_Interspaced_Short_Palindromic_Repeats
|
|
gptkbp:function
|
adaptive immune system in prokaryotes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRISPR
|
|
gptkbp:mechanismOfAction
|
recognizes and cuts foreign DNA
|
|
gptkbp:notableFor
|
gptkb:agricultural_machinery
gene therapy
disease modeling
functional genomics
|
|
gptkbp:patent
|
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
|
|
gptkbp:regulates
|
phage resistance
|
|
gptkbp:relatedTo
|
gptkb:CRISPR-Cas12
gptkb:gene_drive
gptkb:CRISPR-Cas9
gptkb:CRISPR_interference
|
|
gptkbp:sequence
|
repetitive DNA sequence
|
|
gptkbp:spacerOrigin
|
plasmid DNA
viral DNA
|
|
gptkbp:usedFor
|
genome editing
gene activation
gene knockout
gene repression
|
|
gptkbp:usedIn
|
plants
microorganisms
animal models
human cells
mammalian cells
|
|
gptkbp:bfsParent
|
gptkb:biotechnology
|
|
gptkbp:bfsLayer
|
4
|