Cyclin-dependent kinase 1

URI: https://gptkb.org/entity/Cyclin-dependent_kinase_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy CDC25 phosphatase
gptkbp:alternativeName gptkb:cell_division_control_protein_2_homolog
gptkb:CDC2
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy gptkb:Paul_Nurse
gptkbp:EC_number 2.7.11.22
gptkbp:function regulation of cell cycle
mitosis regulation
G2/M transition
gptkbp:gene gptkb:CDK1
gptkbp:GO_term GO:0004693
https://www.w3.org/2000/01/rdf-schema#label Cyclin-dependent kinase 1
gptkbp:inhibitedBy gptkb:p21
gptkb:p27
gptkbp:interactsWith gptkb:cyclin_A
gptkb:cyclin_B1
gptkbp:locatedOnChromosome gptkb:10q21.2
gptkbp:molecularWeight 34 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInYeast gptkb:CDC28
gptkbp:part_of_complex cyclin B-CDK1 complex
maturation promoting factor (MPF)
gptkbp:PDB 4YC3
gptkbp:phosphorylates gptkb:histone_H1
gptkb:p53
lamin proteins
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates regulated by phosphorylation
mitotic exit
mitotic entry
regulated by cyclin binding
regulated by proteolysis
gptkbp:requires cell division
cytokinesis
chromosome condensation
nuclear envelope breakdown
spindle formation
centrosome separation
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:P06493
gptkbp:bfsParent gptkb:CDK1_gene
gptkb:CDK1
gptkbp:bfsLayer 6