|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:ATR
|
|
gptkbp:alternativeName
|
CHK1
Checkpoint kinase 1
Serine/threonine-protein kinase Chk1
|
|
gptkbp:associatedWith
|
gptkb:cancer
genomic instability
|
|
gptkbp:chromosomeArm
|
11q24.2
|
|
gptkbp:discoveredBy
|
Lee et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
1111
ENSG00000113758
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
Checkpoint kinase 1
|
|
gptkbp:function
|
DNA damage response
serine/threonine-protein kinase
cell cycle checkpoint control
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
16627
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHEK1
|
|
gptkbp:inhibitedBy
|
CHK1 inhibitors
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
chemoresistance
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Chek1
|
|
gptkbp:pathway
|
cell cycle
DNA damage response
p53 signaling pathway
|
|
gptkbp:PDB
|
2E9N
1IA8
4FSN
|
|
gptkbp:phosphorylates
|
gptkb:CDC25C
gptkb:p53
CDC25A
|
|
gptkbp:regulates
|
apoptosis
DNA repair
cell cycle arrest
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
anticancer drugs
LY2606368
SRA737
prexasertib
rabusertib
|
|
gptkbp:UniProtID
|
O14757
|
|
gptkbp:bfsParent
|
gptkb:BRIP1
gptkb:CDC25C
|
|
gptkbp:bfsLayer
|
7
|