cyclin dependent kinase 1

URI: https://gptkb.org/entity/cyclin_dependent_kinase_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alias gptkb:cell_division_control_protein_2_homolog
gptkb:CDC2
gptkbp:biologicalProcess cell division
protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
mitotic spindle assembly
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy gptkb:Paul_Nurse
gptkbp:EC_number 2.7.11.22
gptkbp:encodedBy gptkb:CDK1_gene
gptkbp:Entrez_Gene_ID gptkb:CDK1
gptkb:ENSG00000170312
gptkbp:function cell cycle regulation
mitosis regulation
phosphorylation of proteins
gptkbp:gene gptkb:CDK1
gptkbp:HGNC_ID HGNC:1722
https://www.w3.org/2000/01/rdf-schema#label cyclin dependent kinase 1
gptkbp:inhibitedBy gptkb:p21
gptkb:p27
gptkbp:interactsWith gptkb:CDC25C
gptkb:cyclin_A
gptkb:cyclin_B1
gptkbp:involves apoptosis
DNA damage response
tumorigenesis
gptkbp:KEGGID gptkb:hsa:983
gptkbp:locatedOnChromosome gptkb:10q21.2
gptkbp:OMIM 116940
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Cdk1
gptkbp:orthologInYeast gptkb:CDC28
gptkbp:PDB 4YC3
gptkbp:phosphorylates gptkb:histone_H1
lamin proteins
nuclear pore complex proteins
gptkbp:Reactome gptkb:R-HSA-69231
gptkbp:RefSeq NP_001777.1
gptkbp:regulates activated by cyclin binding
activated by dephosphorylation at Thr14 and Tyr15
inhibited by phosphorylation at Tyr15
gptkbp:requires mitotic entry
gptkbp:significance cancer therapy target
gptkbp:target CDK inhibitors
gptkbp:UniProtID gptkb:P06493
gptkbp:bfsParent gptkb:HGNC:1513
gptkbp:bfsLayer 6