|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Fas_ligand
gptkb:TNFSF6
gptkb:FasL
|
|
gptkbp:binds
|
gptkb:CD95
|
|
gptkbp:cleavage
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:encodedBy
|
gptkb:FASLG_gene
|
|
gptkbp:Entrez_Gene_ID
|
356
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
activated T cells
some tumor cells
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:foundIn
|
humans
mice
other mammals
|
|
gptkbp:function
|
induces apoptosis
|
|
gptkbp:homologInRat
|
Fasl
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD95L
|
|
gptkbp:inducedBy
|
cell death
apoptosis in Fas-expressing cells
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
gptkb:TRAIL
|
|
gptkbp:locatedOnChromosome
|
1q23
|
|
gptkbp:location
|
gptkb:cell_membrane
soluble form in extracellular space
|
|
gptkbp:memberOf
|
tumor necrosis factor (TNF) superfamily
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
immune escape in tumors
|
|
gptkbp:OMIM
|
134638
|
|
gptkbp:orthologInMouse
|
Fasl
|
|
gptkbp:pathway
|
immune response
extrinsic apoptotic signaling pathway
T cell homeostasis
peripheral tolerance
|
|
gptkbp:PDB
|
4MSV
|
|
gptkbp:regulates
|
downregulated in some cancers
upregulated by immune activation
|
|
gptkbp:role
|
gptkb:cancer
inflammatory diseases
autoimmune disease
immune system regulation
immune privilege
|
|
gptkbp:structure
|
type II transmembrane protein
|
|
gptkbp:UniProtID
|
gptkb:P48023
|
|
gptkbp:bfsParent
|
gptkb:Fas_ligand
|
|
gptkbp:bfsLayer
|
7
|