Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
SCF-FBW7
SKP1-CUL1-F-box protein complex (FBW7) |
| gptkbp:biologicalProcess |
cell cycle regulation
protein degradation tumor suppression |
| gptkbp:component |
gptkb:RBX1
CUL1 SKP1 FBW7 |
| gptkbp:function |
E3 ubiquitin ligase
ubiquitination of target proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
SCF(FBW7) complex
|
| gptkbp:mutationAssociatedWith |
cancer development
|
| gptkbp:regulates |
apoptosis
cell proliferation |
| gptkbp:target |
gptkb:MCL1
gptkb:c-Myc gptkb:mTOR gptkb:Notch gptkb:cyclin_E SREBP |
| gptkbp:bfsParent |
gptkb:CCNE1
|
| gptkbp:bfsLayer |
7
|