|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:RICK
CARD-containing kinase
CARDIAK
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
gptkb:Blau_syndrome
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
researchers in the late 1990s
|
|
gptkbp:domain
|
gptkb:CARD_domain
kinase domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000104312
8767
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
immune cells
monocytes
|
|
gptkbp:fullName
|
gptkb:Receptor-interacting_serine/threonine-protein_kinase_2
|
|
gptkbp:function
|
signal transduction
kinase activity
immune response regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:10020
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RIPK2
|
|
gptkbp:inhibitedBy
|
gptkb:GSK583
gptkb:Ponatinib
gptkb:WEHI-345
|
|
gptkbp:interactsWith
|
gptkb:TAK1
gptkb:NOD2
gptkb:TRAF6
gptkb:NOD1
gptkb:XIAP
|
|
gptkbp:length
|
541 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q21.3
gptkb:chromosome_8q21.3
8
|
|
gptkbp:molecularWeight
|
61 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Ripk2
gptkb:rat_Ripk2
|
|
gptkbp:pathway
|
gptkb:NOD-like_receptor_signaling_pathway
|
|
gptkbp:phosphorylates
|
Ser176
Ser355
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
NF-kappaB signaling
MAPK signaling
|
|
gptkbp:UniProtID
|
gptkb:O43353
|
|
gptkbp:bfsParent
|
gptkb:Death_Domain
gptkb:Receptor-interacting_protein_kinase_(RIPK)_family
gptkb:P78527
gptkb:NGFR_gene
|
|
gptkbp:bfsLayer
|
7
|