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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CAMKKA
gptkb:CAMKKB
gptkb:CaM-KK2
gptkb:CaMKK2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:type_2_diabetes
prostate cancer
obesity
|
|
gptkbp:biologicalProcess
|
signal transduction
regulation of cell proliferation
kinase activity
cellular response to calcium ion
|
|
gptkbp:encodes
|
gptkb:CaMKK2_protein
|
|
gptkbp:Entrez_Gene_ID
|
10645
ENSG00000157456
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
liver
pancreas
|
|
gptkbp:fullName
|
gptkb:Calcium/calmodulin-dependent_protein_kinase_kinase_2
|
|
gptkbp:function
|
involved in neuronal development
involved in calcium signaling pathway
phosphorylates and activates CAMK1 and CAMK4
regulates AMPK activity
regulates energy balance and metabolism
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:23247
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CAMKK2
|
|
gptkbp:inhibitedBy
|
gptkb:STO-609
|
|
gptkbp:locatedOnChromosome
|
12
|
|
gptkbp:location
|
12q24.2
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Camkk2
gptkb:rat_Camkk2
|
|
gptkbp:PDB
|
gptkb:6BKU
2ZV2
6CMJ
|
|
gptkbp:phosphorylates
|
gptkb:CAMK1
gptkb:CAMK4
AMPK alpha subunit
|
|
gptkbp:regulates
|
gptkb:AMP-activated_protein_kinase_(AMPK)
gptkb:CAMK1
gptkb:CAMK4
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q96RR4
|
|
gptkbp:bfsParent
|
gptkb:CKK
|
|
gptkbp:bfsLayer
|
7
|