|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CaMKK2
CaM-kinase kinase 2
|
|
gptkbp:associatedWith
|
metabolic syndrome (mouse model)
obesity (mouse model)
type 2 diabetes (mouse model)
|
|
gptkbp:biologicalProcess
|
signal transduction
protein kinase activity
calcium-mediated signaling
|
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gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:Entrez_Gene_ID
|
55994
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.1
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
liver
|
|
gptkbp:fullName
|
calcium/calmodulin-dependent protein kinase kinase 2
|
|
gptkbp:function
|
serine/threonine protein kinase
activates AMPK, CAMK1, CAMK4
|
|
gptkbp:gene
|
Camkk2
|
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gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse Camkk2
|
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gptkbp:interactsWith
|
gptkb:calmodulin
gptkb:CAMK1
gptkb:CAMK4
AMPK alpha subunit
|
|
gptkbp:length
|
587 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12 D1
|
|
gptkbp:molecularWeight
|
65 kDa
|
|
gptkbp:mutationAssociatedWith
|
affects energy metabolism
alters glucose homeostasis
impacts learning and memory
|
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gptkbp:organism
|
gptkb:Mus_musculus
|
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gptkbp:orthologIn
|
human CAMKK2
|
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gptkbp:pathway
|
AMPK signaling pathway
calcium signaling pathway
|
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gptkbp:phosphorylates
|
gptkb:AMPK
gptkb:CAMK1
gptkb:CAMK4
|
|
gptkbp:postTranslationalModification
|
phosphorylation
autophosphorylation
|
|
gptkbp:RefSeq
|
NM_001253858
|
|
gptkbp:regulates
|
activated by calcium/calmodulin
inhibited by STO-609
|
|
gptkbp:structure
|
contains calmodulin-binding domain
contains protein kinase domain
|
|
gptkbp:UniProtID
|
Q8CIM2
|
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gptkbp:bfsParent
|
gptkb:CAMKK2
|
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gptkbp:bfsLayer
|
8
|