|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CAMKK2
gptkb:CAMKKB
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
prostate cancer
obesity
|
|
gptkbp:biologicalProcess
|
signal transduction
neuronal development
metabolic regulation
|
|
gptkbp:discoveredBy
|
gptkb:Howard_Schulman
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:domain
|
protein kinase domain
calmodulin-binding domain
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.17
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
liver
|
|
gptkbp:fullName
|
gptkb:Calcium/calmodulin-dependent_protein_kinase_kinase_2
|
|
gptkbp:function
|
serine/threonine protein kinase
phosphorylates and activates CaMKI and CaMKIV
phosphorylates and activates AMPK
|
|
gptkbp:gene
|
gptkb:CAMKK2
|
|
gptkbp:GO
|
gptkb:GO:0004674
GO:0005524
|
|
gptkbp:hasIsoform
|
CaMKK2 alpha
CaMKK2 beta
|
|
gptkbp:HGNC_ID
|
23299
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CaMKK2 protein
|
|
gptkbp:inhibitedBy
|
gptkb:STO-609
|
|
gptkbp:locatedOnChromosome
|
12q24.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus CaMKK2
Rattus norvegicus CaMKK2
|
|
gptkbp:pathway
|
AMPK signaling pathway
calcium signaling pathway
|
|
gptkbp:PDB
|
gptkb:6BKU
2ZV2
|
|
gptkbp:phosphorylates
|
Ser511
Thr85
|
|
gptkbp:postTranslationalModification
|
phosphorylation
autophosphorylation
|
|
gptkbp:RefSeq
|
NP_001220.2
|
|
gptkbp:regulates
|
activated by calcium/calmodulin
|
|
gptkbp:UniProtID
|
gptkb:Q96RR4
|
|
gptkbp:bfsParent
|
gptkb:CAMKK2
|
|
gptkbp:bfsLayer
|
8
|