|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CAMKKB
CAMK kinase 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:metabolic_syndrome
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
Hitoshi Soderling
|
|
gptkbp:discoveredIn
|
1999
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|
gptkbp:Entrez_Gene_ID
|
10645
ENSG00000157456
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|
gptkbp:enzymeCommissionNumber
|
2.7.11.17
|
|
gptkbp:fullName
|
gptkb:Calcium/calmodulin-dependent_protein_kinase_kinase_2
|
|
gptkbp:function
|
serine/threonine protein kinase
phosphorylates and activates CaMKI and CaMKIV
regulates AMP-activated protein kinase (AMPK)
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gptkbp:gene
|
gptkb:CAMKK2
|
|
gptkbp:HGNC_ID
|
HGNC:2320
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CaM-KK2
|
|
gptkbp:inhibitedBy
|
gptkb:STO-609
|
|
gptkbp:locatedOnChromosome
|
12q24.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Camkk2
gptkb:rat_Camkk2
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
AMPK signaling pathway
calcium signaling pathway
|
|
gptkbp:PDB
|
2ZV2
|
|
gptkbp:phosphorylates
|
gptkb:CaMKI
gptkb:CaMKIV
gptkb:AMPK
|
|
gptkbp:postTranslationalModification
|
phosphorylation
autophosphorylation
|
|
gptkbp:RefSeq
|
NM_145859
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell metabolism
neuronal signaling
activated by calcium/calmodulin
|
|
gptkbp:structure
|
contains calmodulin-binding domain
contains protein kinase domain
|
|
gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
gptkb:testis
brain
liver
|
|
gptkbp:UniProtID
|
gptkb:Q96RR4
|
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gptkbp:bfsParent
|
gptkb:CAMKK2
|
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gptkbp:bfsLayer
|
8
|