|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CAMKKB
CAMKK beta
CaMKK-beta
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
prostate cancer
obesity
|
|
gptkbp:biologicalProcess
|
neuronal development
protein serine/threonine kinase activity
calcium signaling pathway
regulation of cell metabolism
energy homeostasis
|
|
gptkbp:encodedBy
|
CAMKK2 gene
|
|
gptkbp:Entrez_Gene_ID
|
10645
ENSG00000157456
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.17
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
liver
|
|
gptkbp:fullName
|
gptkb:Calcium/calmodulin-dependent_protein_kinase_kinase_2
|
|
gptkbp:function
|
phosphorylates and activates CaMKI and CaMKIV
phosphorylates and activates AMPK
|
|
gptkbp:gene
|
gptkb:CAMKK2
|
|
gptkbp:HGNC_ID
|
HGNC:23247
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CaMKK2
|
|
gptkbp:inhibitedBy
|
gptkb:STO-609
|
|
gptkbp:interactsWith
|
gptkb:CaMKI
gptkb:CaMKIV
gptkb:calmodulin
gptkb:AMPK
|
|
gptkbp:length
|
588
|
|
gptkbp:locatedOnChromosome
|
12q24.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
65 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2ZV2
|
|
gptkbp:phosphorylates
|
Serine 511
Threonine 85
|
|
gptkbp:postTranslationalModification
|
phosphorylation
autophosphorylation
|
|
gptkbp:RefSeq
|
NM_145859
|
|
gptkbp:regulates
|
activated by Ca2+/calmodulin
autoinhibited in absence of Ca2+/calmodulin
|
|
gptkbp:UniProtID
|
gptkb:Q96RR4
|
|
gptkbp:bfsParent
|
gptkb:CAMKK2
|
|
gptkbp:bfsLayer
|
8
|