Btk (Bruton's tyrosine kinase)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	Bruton's agammaglobulinemia tyrosine kinase
gptkbp:associatedWith	gptkb:X-linked_agammaglobulinemia
gptkbp:biologicalProcess	tyrosine kinase activity
gptkbp:discoveredBy	gptkb:Ogden_Bruton
gptkbp:EC_number	2.7.10.2
gptkbp:encodedBy	gptkb:BTK_gene
gptkbp:expressedIn	gptkb:B_cells myeloid cells
gptkbp:function	signal transduction B cell development B cell receptor signaling
gptkbp:gene	gptkb:BTK
gptkbp:inhibitedBy	gptkb:acalabrutinib gptkb:ibrutinib zanubrutinib
gptkbp:locatedOnChromosome	Xq21.3-q22
gptkbp:location	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:mutationAssociatedWith	gptkb:immunodeficiency
gptkbp:OMIM	300300
gptkbp:orthologInMouse	Btk (mouse)
gptkbp:PDB	3GEN
gptkbp:phosphorylates	gptkb:BLNK gptkb:PLCγ2
gptkbp:proteinFamily	gptkb:Tec_family_kinases
gptkbp:regulates	gptkb:NF-κB_pathway calcium signaling apoptosis in B cells
gptkbp:structure	gptkb:PH_domain kinase domain SH2 domain SH3 domain TH domain
gptkbp:targetOfDrug	gptkb:acalabrutinib gptkb:ibrutinib evobrutinib spebrutinib tirabrutinib zanubrutinib
gptkbp:treatment	gptkb:mantle_cell_lymphoma gptkb:Waldenström's_macroglobulinemia multiple sclerosis chronic lymphocytic leukemia rheumatoid arthritis
gptkbp:UniProtID	Q06187
gptkbp:bfsParent	gptkb:B_cell_receptor_signaling_pathway
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Btk (Bruton's tyrosine kinase)