Btk (Bruton's tyrosine kinase)

URI: https://gptkb.org/entity/Btk_(Bruton's_tyrosine_kinase)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName Bruton's agammaglobulinemia tyrosine kinase
gptkbp:associatedWith gptkb:X-linked_agammaglobulinemia
gptkbp:biologicalProcess tyrosine kinase activity
gptkbp:discoveredBy gptkb:Ogden_Bruton
gptkbp:EC_number 2.7.10.2
gptkbp:encodedBy gptkb:BTK_gene
gptkbp:expressedIn gptkb:B_cells
myeloid cells
gptkbp:function signal transduction
B cell development
B cell receptor signaling
gptkbp:gene gptkb:BTK
https://www.w3.org/2000/01/rdf-schema#label Btk (Bruton's tyrosine kinase)
gptkbp:inhibitedBy gptkb:acalabrutinib
gptkb:ibrutinib
zanubrutinib
gptkbp:locatedOnChromosome Xq21.3-q22
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:mutationAssociatedWith immunodeficiency
gptkbp:OMIM 300300
gptkbp:orthologInMouse Btk (mouse)
gptkbp:PDB 3GEN
gptkbp:phosphorylates gptkb:BLNK
gptkb:PLCγ2
gptkbp:proteinFamily gptkb:Tec_family_kinases
gptkbp:regulates gptkb:NF-κB_pathway
calcium signaling
apoptosis in B cells
gptkbp:structure gptkb:PH_domain
kinase domain
SH2 domain
SH3 domain
TH domain
gptkbp:targetOfDrug gptkb:acalabrutinib
gptkb:ibrutinib
evobrutinib
spebrutinib
tirabrutinib
zanubrutinib
gptkbp:treatment gptkb:mantle_cell_lymphoma
gptkb:Waldenström's_macroglobulinemia
multiple sclerosis
chronic lymphocytic leukemia
rheumatoid arthritis
gptkbp:UniProtID Q06187
gptkbp:bfsParent gptkb:B_cell_receptor_signaling_pathway
gptkbp:bfsLayer 7