Hereditary Breast and Ovarian Cancer Syndrome
GPTKB entity
Statements (37)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
hereditary cancer syndrome |
| gptkbp:affects |
both men and women
|
| gptkbp:alsoKnownAs |
gptkb:HBOC
|
| gptkbp:associatedWith |
family history of breast or ovarian cancer
|
| gptkbp:chemoprevention |
gptkb:tamoxifen
raloxifene |
| gptkbp:diagnosedBy |
genetic testing
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:geneticCounselingRecommended |
yes
|
| https://www.w3.org/2000/01/rdf-schema#label |
Hereditary Breast and Ovarian Cancer Syndrome
|
| gptkbp:ICD-10_code |
Z15.01
|
| gptkbp:inheritsFrom |
autosomal dominant manner
|
| gptkbp:managedBy |
risk-reducing surgery
chemoprevention increased surveillance |
| gptkbp:MeSH_ID |
D054549
|
| gptkbp:mutationAssociatedWith |
gptkb:BRCA1_gene
gptkb:BRCA2_gene |
| gptkbp:OMIM |
604370
|
| gptkbp:parentDisorder |
hereditary cancer predisposition syndrome
|
| gptkbp:prevalence |
about 1 in 400 people
|
| gptkbp:riskFactor |
gptkb:cancer
pancreatic cancer prostate cancer |
| gptkbp:riskOfBreastCancerByAge70 |
up to 69% (BRCA2 mutation carriers)
up to 72% (BRCA1 mutation carriers) |
| gptkbp:riskOfOvarianCancerByAge70 |
up to 17% (BRCA2 mutation carriers)
up to 44% (BRCA1 mutation carriers) |
| gptkbp:riskReducingSurgery |
mastectomy
salpingo-oophorectomy |
| gptkbp:screeningRecommendations |
CA-125 blood test
annual breast MRI annual mammogram transvaginal ultrasound for ovaries |
| gptkbp:bfsParent |
gptkb:Breast_cancer_type_1_susceptibility_protein
|
| gptkbp:bfsLayer |
7
|