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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alsoKnownAs
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gptkb:Binding_immunoglobulin_protein
gptkb:GRP78
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gptkbp:cellularComponent
|
endoplasmic reticulum lumen
|
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gptkbp:discoveredBy
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gptkb:Kazutoshi_Mori
gptkb:Peter_Walter
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gptkbp:expressedIn
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ubiquitous
upregulated by ER stress
|
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gptkbp:family
|
gptkb:heat_shock_protein_70_family
|
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gptkbp:function
|
protein folding
unfolded protein response
ATP binding
protein binding
molecular chaperone
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gptkbp:gene
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gptkb:HSPA5
|
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gptkbp:GOProcess
|
protein folding
response to unfolded protein
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https://www.w3.org/2000/01/rdf-schema#label
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Bip (protein)
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gptkbp:interactsWith
|
co-chaperones
J-domain proteins
misfolded proteins
nucleotide exchange factors
|
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gptkbp:involvedIn
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ER stress response
protein translocation into ER
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gptkbp:locatedIn
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gptkb:endoplasmic_reticulum
|
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gptkbp:locatedOnChromosome
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gptkb:chromosome_9q33.3
|
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gptkbp:molecularWeight
|
78 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Drosophila_BiP
gptkb:yeast_Kar2p
|
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gptkbp:PDB
|
gptkb:3LDL
gptkb:5E84
|
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gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
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gptkbp:regulates
|
gptkb:ATF6
gptkb:IRE1
gptkb:PERK
protein quality control
activation of ER stress sensors
|
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gptkbp:sequence
|
available in UniProt P11021
|
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gptkbp:significance
|
implicated in cancer
implicated in neurodegenerative diseases
marker for ER stress
|
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gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
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gptkbp:structure
|
contains ATPase domain
contains substrate-binding domain
|
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gptkbp:UniProtID
|
P11021
|
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gptkbp:bfsParent
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gptkb:BIP
|
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gptkbp:bfsLayer
|
5
|