Beta-1 adrenergic receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:alternativeName	gptkb:β1-adrenergic_receptor gptkb:β1AR gptkb:beta-1_adrenoceptor
gptkbp:discoveredBy	gptkb:Robert_Lefkowitz
gptkbp:EC_number	7.6.2.1
gptkbp:encodedBy	gptkb:ADRB1_gene
gptkbp:enemyOf	gptkb:atenolol gptkb:metoprolol gptkb:acebutolol gptkb:betaxolol gptkb:bisoprolol gptkb:carvedilol gptkb:dobutamine gptkb:isoproterenol gptkb:labetalol gptkb:nebivolol propranolol esmolol
gptkbp:Entrez_Gene_ID	153
gptkbp:expressedIn	gptkb:cardiac_myocytes gptkb:juxtaglomerular_cells
gptkbp:foundIn	gptkb:human mammals
gptkbp:function	increases heart rate increases cardiac contractility mediates effects of adrenaline and noradrenaline stimulates renin release
gptkbp:HGNC_ID	gptkb:ADRβ1
gptkbp:locatedIn	gptkb:adipose_tissue gptkb:kidney heart
gptkbp:locatedOnChromosome	10q25.3
gptkbp:modulatedBy	gptkb:catecholamines phosphorylation desensitization
gptkbp:OMIM	109630
gptkbp:receptorSubtype	gptkb:beta-adrenergic_receptor
gptkbp:recipient	gptkb:adrenergic_receptor
gptkbp:significance	involved in heart failure involved in hypertension target for beta blockers
gptkbp:structure	seven transmembrane domains
gptkbp:type	activates adenylate cyclase activates protein kinase A increases cAMP
gptkbp:UniProtID	P08588
gptkbp:bfsParent	gptkb:CHEMBL1787 gptkb:CHEMBL521 gptkb:CHEMBL191
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Beta-1 adrenergic receptor