|
gptkbp:instanceOf
|
gptkb:drug
non-selective beta blocker
alpha-1 blocker
|
|
gptkbp:approvedBy
|
gptkb:Europe
gptkb:United_States
|
|
gptkbp:ATCCode
|
C07AG02
|
|
gptkbp:bioavailability
|
25%
|
|
gptkbp:brand
|
Coreg
Dilatrend
Eucardic
Kredex
|
|
gptkbp:CASNumber
|
72956-09-3
|
|
gptkbp:contraindication
|
asthma
severe liver impairment
second or third degree AV block
|
|
gptkbp:developedBy
|
gptkb:Boehringer_Mannheim
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:eliminationHalfLife
|
7-10 hours
|
|
gptkbp:firstApproval
|
1995 (US)
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:hasMolecularFormula
|
C24H26N2O4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
carvedilol
|
|
gptkbp:KEGGID
|
D00245
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
blocks alpha-1 adrenergic receptors
blocks beta-adrenergic receptors
|
|
gptkbp:MedlinePlusID
|
a697042
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
406.48 g/mol
|
|
gptkbp:pregnancyCategory
|
gptkb:C_(Australia)
C (US)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:PubChem_CID
|
2585
CHEMBL229
DB01136
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:RxNormID
|
197798
|
|
gptkbp:sideEffect
|
dizziness
fatigue
weight gain
hypotension
bradycardia
|
|
gptkbp:UNII
|
0K47W6QKE3
|
|
gptkbp:usedFor
|
heart failure
hypertension
left ventricular dysfunction after myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:Beta-1_adrenergic_receptor
gptkb:beta-adrenergic_receptors
gptkb:ADRB2_gene
|
|
gptkbp:bfsLayer
|
7
|