Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:G_protein-coupled_receptor
adrenergic receptor |
| gptkbp:activatedBy |
norepinephrine
epinephrine |
| gptkbp:associatedWith |
gptkb:arrhythmia
heart failure hypertension |
| gptkbp:discoveredBy |
gptkb:Robert_Lefkowitz
|
| gptkbp:encodedBy |
gptkb:ADRB1_gene
|
| gptkbp:enemyOf |
gptkb:atenolol
gptkb:metoprolol gptkb:dobutamine gptkb:isoproterenol beta blocker |
| gptkbp:foundIn |
gptkb:kidney
heart adipose tissue |
| gptkbp:function |
increases heart rate
increases cardiac contractility stimulates renin release |
| https://www.w3.org/2000/01/rdf-schema#label |
β1-adrenergic receptor
|
| gptkbp:locatedOn |
gptkb:plasma_membrane
|
| gptkbp:locatedOnChromosome |
chromosome 10q25.3
|
| gptkbp:orthologIn |
β2-adrenergic receptor
β3-adrenergic receptor |
| gptkbp:structure |
7 transmembrane domains
|
| gptkbp:targetOfDrug |
antiarrhythmic drugs
antihypertensive drugs |
| gptkbp:type |
activates adenylate cyclase
increases cAMP |
| gptkbp:UniProtID |
P08588
|
| gptkbp:bfsParent |
gptkb:Beta-1_adrenergic_receptor
|
| gptkbp:bfsLayer |
7
|