Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer |
| gptkbp:composed_of |
gptkb:BRCA1_protein
gptkb:BARD1_protein |
| gptkbp:function |
cell cycle regulation
|
| gptkbp:has_role |
tumor suppression
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1-BARD1 complex
|
| gptkbp:initiated_by |
tumorigenesis
|
| gptkbp:interacts_with |
gptkb:BRCA1
gptkb:p53 gptkb:BARD1 gptkb:RAD51 |
| gptkbp:involved_in |
DNA damage response
DNA repair genomic stability |
| gptkbp:is_associated_with |
DNA repair disorders
|
| gptkbp:is_characterized_by |
protein-protein interactions
E3 ubiquitin ligase activity BARD1-BRCA1 interaction BRCA1-BARD1 interaction |
| gptkbp:is_essential_for |
DNA double-strand break repair
|
| gptkbp:is_involved_in |
DNA replication
apoptosis regulation cellular homeostasis cellular metabolism cellular stress response chromatin remodeling immune response signal transduction cellular function cellular proliferation cellular response to stress chromosomal stability transcription regulation cellular aging cellular differentiation cellular development metastasis cellular signaling pathways cellular communication cellular signaling cellular repair mechanisms cellular adaptation metabolic regulation cellular response to DNA damage tumor microenvironment interactions cellular repair pathways cellular repair processes cellular integrity cellular homeostasis maintenance genetic stability maintenance |
| gptkbp:is_linked_to |
gptkb:BRCA1_mutations
BARD1 mutations |
| gptkbp:is_part_of |
DNA repair pathway
|
| gptkbp:is_regulated_by |
gptkb:ATM_protein
gptkb:ATR_protein |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
cancer therapies
|
| gptkbp:localization |
gptkb:Atom
|
| gptkbp:regulates |
homologous recombination
|
| gptkbp:bfsParent |
gptkb:BRCA1
|
| gptkbp:bfsLayer |
6
|