Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:anemia gptkb:neurodegenerative_diseases |
| gptkbp:clinical_trial |
target for cancer therapy
|
| gptkbp:discovered_by |
Dr. David Cortez
|
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_studies |
increased cancer susceptibility
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATR protein
|
| gptkbp:inhibitor_type |
small molecule inhibitors
|
| gptkbp:initiated_by |
CCT241533
VE-821 |
| gptkbp:interacts_with |
gptkb:ATM_protein
gptkb:BRCA1 gptkb:p53 |
| gptkbp:involved_in |
DNA replication
DNA repair apoptosis regulation cell cycle regulation cellular homeostasis cellular metabolism cellular stress response chromatin remodeling immune response signal transduction cellular function homologous recombination cellular proliferation cellular response to stress cellular senescence transcription regulation tumor suppression non-homologous end joining cellular aging cellular differentiation genomic stability cellular development cellular signaling pathways cellular repair mechanisms cellular response to DNA damage telomere maintenance cellular death pathways cellular differentiation pathways cellular growth control cellular repair pathways cellular apoptosis cellular survival pathways cellular integrity double-strand break repair single-strand break repair |
| gptkbp:is_expressed_in |
upregulated in response to DNA damage
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:orthologs |
ATR in other species
|
| gptkbp:pathway |
ATR-Chk1 pathway
|
| gptkbp:promoter |
gptkb:ATR
|
| gptkbp:related_to |
gptkb:checkpoint_kinase_2
checkpoint kinase 1 |
| gptkbp:research_focus |
targeting in cancer treatment
|
| gptkbp:role |
sensing DNA replication stress
|
| gptkbp:type |
serine/threonine kinase
|
| gptkbp:bfsParent |
gptkb:CHEK2
|
| gptkbp:bfsLayer |
6
|