Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein
|
| gptkbp:associatedWith |
cancer
|
| gptkbp:community |
upregulated in response to DNA damage
|
| gptkbp:constructionMaterial |
BRCA1
p53 Chk1 |
| gptkbp:culturalEvents |
ATR_in_other_species
|
| gptkbp:diseaseResistance |
ataxia telangiectasia-like disorder
|
| gptkbp:function |
DNA damage response
|
| gptkbp:geneticDiversity |
ATR
associated with genomic instability |
| https://www.w3.org/2000/01/rdf-schema#label |
ATR protein
|
| gptkbp:interactsWith |
gptkb:ATM_protein
BRCA1 p53 |
| gptkbp:involvedIn |
DNA replication
DNA repair aging apoptosis cell cycle regulation cellular homeostasis chromatin remodeling immune response protein synthesis signal transduction homologous recombination cellular proliferation cellular response to stress cellular senescence transcription regulation tumor suppression cellular differentiation cellular responses to stimuli DNA methylation cellular signaling pathways neurodegeneration cellular adhesion cellular signaling telomere shortening cellular repair mechanisms metabolic regulation cellular interactions cellular apoptosis cellular growth cellular responses to environmental changes cellular responses to radiation cellular migration cellular responses to stressors cellular invasion cellular responses to bacterial infections cellular responses to chemical agents cellular responses to viral infections genome stability maintenance |
| gptkbp:is_a_route_for |
ATR-Chk1_signaling_pathway
|
| gptkbp:isActiveIn |
AZD6738
CCT241533 M6620 VE-821 |
| gptkbp:location |
nucleus
|
| gptkbp:research |
target for cancer therapy
|
| gptkbp:role |
telomere maintenance
checkpoint activation replication stress response |
| gptkbp:type |
serine/threonine kinase
|