Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:addressed |
support groups
|
| gptkbp:affects |
quality of life
DNA repair insurance coverage family planning reproductive choices |
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer increased risk of cardiovascular disease increased mortality risk increased risk of liver cancer increased risk of melanoma increased risk of pancreatic neuroendocrine tumors increased risk of testicular cancer increased risk of thyroid cancer |
| gptkbp:can_be_discussed_with |
healthcare providers
|
| gptkbp:can_be_screened_in |
high-risk populations
|
| gptkbp:can_cause |
tumorigenesis
|
| gptkbp:can_detect |
blood test
|
| gptkbp:can_lead_to |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
informed decision-making community awareness initiatives psychological impact financial implications early onset of cancer chemotherapy resistance |
| gptkbp:discovered_by |
gptkb:1990
|
| gptkbp:has_influence_on |
treatment options
|
| https://www.w3.org/2000/01/rdf-schema#label |
BRCA1 mutations
|
| gptkbp:influence |
treatment decisions
clinical management |
| gptkbp:inherits_from |
either parent
autosomal dominant inheritance |
| gptkbp:investment |
gptkb:Oncology
gptkb:pancreatic_cancer |
| gptkbp:is_discussed_in |
genetic counseling
|
| gptkbp:is_evaluated_by |
oncologists
|
| gptkbp:is_explored_in |
research studies
genetic research |
| gptkbp:is_linked_to |
increased risk of skin cancer
male breast cancer increased risk of bladder cancer increased risk of colorectal cancer increased risk of endometrial cancer reduced fertility increased risk of sarcoma |
| gptkbp:is_located_in |
chromosome 17
|
| gptkbp:is_managed_by |
preventive measures
surveillance strategies |
| gptkbp:is_often_seen_in |
gptkb:Ashkenazi_Jewish_population
|
| gptkbp:is_part_of |
personalized medicine approaches
multigene panel testing |
| gptkbp:is_recognized_by |
family history
sequencing techniques |
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:may_be_followed_by |
regular screenings
|
| gptkbp:requires |
lifestyle changes
lifestyle modifications psychosocial support ongoing monitoring preventive surgery |
| gptkbp:resulted_in |
loss of function
|
| gptkbp:screenings |
genetic testing
|
| gptkbp:treatment |
PARP inhibitors
|
| gptkbp:bfsParent |
gptkb:HER2-negative_breast_cancer
gptkb:triple-negative_breast_cancer |
| gptkbp:bfsLayer |
6
|