|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Autism_spectrum_disorder
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:Major_depressive_disorder
gptkb:Huntington's_disease
gptkb:Bipolar_disorder
Epilepsy
Obesity
Schizophrenia
|
|
gptkbp:category
|
growth factor
neurotrophin
|
|
gptkbp:discoveredBy
|
gptkb:Yves-Alain_Barde
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:BDNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
627
|
|
gptkbp:fullName
|
gptkb:Brain-derived_neurotrophic_factor
|
|
gptkbp:function
|
gptkb:neurotrophin_TRK_receptor_signaling_pathway
gptkb:positive_regulation_of_axonogenesis
gptkb:positive_regulation_of_neuron_differentiation
gptkb:positive_regulation_of_synaptic_transmission
growth factor
promotes growth and differentiation of new neurons and synapses
supports survival of neurons
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BDNF protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p14.1
|
|
gptkbp:location
|
brain
central nervous system
peripheral nervous system
|
|
gptkbp:OMIM
|
113505
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_BDNF_protein
gptkb:rat_BDNF_protein
|
|
gptkbp:PDB
|
gptkb:1BND
gptkb:1DJC
1B8M
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recipient
|
gptkb:p75NTR
gptkb:TrkB
|
|
gptkbp:relatedTo
|
gptkb:depression
gptkb:synaptic_plasticity
memory
learning
neurodegenerative diseases
|
|
gptkbp:sequence
|
human BDNF protein is 247 amino acids
|
|
gptkbp:structure
|
contains a mature domain
contains a pro-domain
contains a signal peptide
|
|
gptkbp:UniProtID
|
gptkb:P23560
|
|
gptkbp:bfsParent
|
gptkb:BDNF_gene
|
|
gptkbp:bfsLayer
|
7
|