|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:depression
gptkb:Huntington's_disease
gptkb:autism_spectrum_disorder
bipolar disorder
epilepsy
schizophrenia
obesity
neurological disorders
eating disorders
anxiety disorders
|
|
gptkbp:biologicalProcess
|
gptkb:synaptic_plasticity
neuronal development
memory formation
|
|
gptkbp:disulfideBond
|
yes
|
|
gptkbp:encodedBy
|
Bdnf gene
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
peripheral tissues
|
|
gptkbp:fullName
|
gptkb:Brain-derived_neurotrophic_factor
|
|
gptkbp:function
|
growth factor
supports survival of existing neurons
encourages growth and differentiation of new neurons and synapses
|
|
gptkbp:GO_term
|
GO:0007267 (cell-cell signaling)
GO:0005169 (neurotrophin TRK receptor binding)
GO:0007613 (memory)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse BDNF protein
|
|
gptkbp:length
|
247 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_2_(mouse)
|
|
gptkbp:maturation
|
119 amino acids
|
|
gptkbp:matureMolecularWeight
|
13.5 kDa
|
|
gptkbp:molecularWeight
|
27 kDa (precursor)
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
gptkb:rat_BDNF_protein
human BDNF protein
|
|
gptkbp:PDB_structure
|
1B8M
|
|
gptkbp:postTranslationalModification
|
cleavage
glycosylation
|
|
gptkbp:recipient
|
gptkb:p75NTR
gptkb:TrkB
|
|
gptkbp:sequenceSimilarity
|
human BDNF protein
|
|
gptkbp:signalPeptide
|
yes
|
|
gptkbp:subcellularLocation
|
synapse
extracellular space
secreted
|
|
gptkbp:UniProtID
|
P21237
|
|
gptkbp:bfsParent
|
gptkb:BDNF_protein
|
|
gptkbp:bfsLayer
|
8
|