Amyloid Precursor Protein

URI: https://gptkb.org/entity/Amyloid_Precursor_Protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:APP
gptkbp:alternativeSplicing	gptkb:APP695 gptkb:APP751 gptkb:APP770
gptkbp:associatedWith	gptkb:Alzheimer's_disease
gptkbp:cleavage	gptkb:amyloid_beta gptkb:alpha-secretase gptkb:beta-secretase gptkb:gamma-secretase soluble APP alpha soluble APP beta
gptkbp:discoveredBy	gptkb:George_Glenner
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:APP_gene
gptkbp:Entrez_Gene_ID	351
gptkbp:expressedIn	gptkb:cancer gptkb:skeletal_muscle gptkb:kidney gptkb:placenta gptkb:testis brain heart liver spleen pancreas
gptkbp:foundIn	gptkb:human gptkb:mouse other mammals
gptkbp:function	cell surface receptor cell adhesion synapse formation neuronal growth
https://www.w3.org/2000/01/rdf-schema#label	Amyloid Precursor Protein
gptkbp:locatedOnChromosome	chromosome 21
gptkbp:location	gptkb:endoplasmic_reticulum gptkb:cell_membrane gptkb:Golgi_apparatus
gptkbp:molecularWeight	~100-140 kDa
gptkbp:mutationAssociatedWith	gptkb:familial_Alzheimer's_disease
gptkbp:OMIM	104760
gptkbp:orthologIn	gptkb:mouse gptkb:zebrafish gptkb:Drosophila_melanogaster right
gptkbp:PDB	3UMH
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:UniProtID	gptkb:P05067
gptkbp:bfsParent	gptkb:APP
gptkbp:bfsLayer	7