Activating Transcription Factor 2

URI: https://gptkb.org/entity/Activating_Transcription_Factor_2
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alternativeName gptkb:CRE-BP1
gptkb:CREB2
gptkb:HB16
ATF-2
TREB7
gptkbp:associatedWith gptkb:cancer
neurological disorders
gptkbp:binds gptkb:cAMP_response_element_(CRE)
gptkbp:discoveredIn 1991
gptkbp:encodedBy gptkb:ATF2_gene
gptkbp:Entrez_Gene_ID 1386
ENSG00000115966
gptkbp:expressedIn various tissues
gptkbp:formsComplexWith gptkb:CREB
gptkb:c-Jun
gptkbp:function transcriptional activation
regulation of gene expression
DNA binding
gptkbp:HGNC_ID HGNC:784
https://www.w3.org/2000/01/rdf-schema#label Activating Transcription Factor 2
gptkbp:involvedIn apoptosis
cell cycle regulation
DNA damage response
cellular stress response
gptkbp:length 505 amino acids
gptkbp:locale gptkb:nucleus
gptkbp:locatedOnChromosome 2q32
gptkbp:memberOf gptkb:ATF/CREB_family
gptkbp:molecularWeight ~74 kDa
gptkbp:OMIM 123811
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1T2K
gptkbp:phosphorylates gptkb:MAPK
gptkb:JNK
gptkb:p38_MAPK
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:RefSeq NM_001880
gptkbp:regulates apoptosis-related genes
immune response genes
cell proliferation genes
transcription of stress-responsive genes
gptkbp:structure basic leucine zipper (bZIP) domain
gptkbp:UniProtID gptkb:P15336
gptkbp:bfsParent gptkb:ATF2
gptkbp:bfsLayer 7