|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CRE-BP1
gptkb:CREB2
gptkb:HB16
TREB7
|
|
gptkbp:associatedWith
|
gptkb:cancer
melanoma
neurodegenerative diseases
|
|
gptkbp:encodes
|
Activating transcription factor 2
|
|
gptkbp:Entrez_Gene_ID
|
1386
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
transcription factor
regulation of gene expression
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATF2 gene
|
|
gptkbp:interactsWith
|
gptkb:c-Jun
gptkb:CBP/p300
gptkb:CREB1
|
|
gptkbp:involvedIn
|
apoptosis
cell cycle regulation
DNA damage response
cellular stress response
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q32
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
altered stress response
|
|
gptkbp:OMIM
|
123811
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Atf2
|
|
gptkbp:phosphorylates
|
gptkb:JNK
gptkb:p38_MAPK
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:ATF/CREB_family
basic leucine zipper (bZIP) domain
|
|
gptkbp:regulates
|
gptkb:TRE_(TPA_response_element)
AP-1 transcription factor activity
CRE (cAMP response element)
stress-activated gene expression
|
|
gptkbp:UniProtID
|
gptkb:P15336
|
|
gptkbp:bfsParent
|
gptkb:ATF2
|
|
gptkbp:bfsLayer
|
7
|