|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:APEX
APE1
APEN
REF-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
DNA binding
transcription coactivator activity
endonuclease activity
|
|
gptkbp:encodes
|
AP endonuclease 1
|
|
gptkbp:Entrez_Gene_ID
|
328
|
|
gptkbp:enzymeCommissionNumber
|
3.1.21.7
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
apurinic/apyrimidinic endodeoxyribonuclease 1
|
|
gptkbp:function
|
DNA repair
redox regulation of transcription factors
|
|
gptkbp:geneLocationAssembly
|
gptkb:GRCh38
|
|
gptkbp:geneLocationEnd
|
20466878
|
|
gptkbp:geneLocationStart
|
20456013
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APEX1
|
|
gptkbp:inhibitedBy
|
CRT0044876
E3330
|
|
gptkbp:length
|
318
|
|
gptkbp:locatedOnChromosome
|
14q11.2
|
|
gptkbp:molecularWeight
|
35.5 kDa
|
|
gptkbp:OMIM
|
107748
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Apex1
|
|
gptkbp:participatedIn
|
base excision repair
|
|
gptkbp:PDB
|
1BIX
1DE8
1DEW
1E9A
1E9N
1E9O
1E9P
1E9Q
1E9R
1E9S
1E9T
1E9U
1E9V
1E9W
1E9X
1E9Y
1E9Z
1FEN
1HD7
1QUM
1QUN
1QUP
1QUR
1QUS
1QUT
1QUV
1QUX
1QVA
1QVB
1QVC
1QVD
1QVE
1QVF
1QVG
1QVH
1QVI
1QVJ
1QVK
1QVL
1QVM
1QVN
1QVO
1QVP
1QVR
1QVS
1QVT
1QVU
1QVV
1QVW
1QVX
1QVY
1QVZ
|
|
gptkbp:regulates
|
gptkb:CREB
gptkb:NF-kB
gptkb:p53
gptkb:HIF-1alpha
gptkb:AP-1
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P27695
|
|
gptkbp:bfsParent
|
gptkb:AP_endonuclease
|
|
gptkbp:bfsLayer
|
7
|