Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:AP_lyase
gptkb:apurinic/apyrimidinic_endonuclease gptkb:APEX gptkb:APE |
| gptkbp:catalyzes |
cleavage of phosphodiester bond at apurinic/apyrimidinic sites
|
| gptkbp:cofactor |
Mg2+
Mn2+ |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:EC_number |
3.1.21.7
|
| gptkbp:foundIn |
gptkb:Bacteria
eukaryotes |
| gptkbp:function |
DNA repair
|
| gptkbp:gene |
gptkb:APEX1
gptkb:APEX2 |
| https://www.w3.org/2000/01/rdf-schema#label |
AP endonuclease
|
| gptkbp:inhibitedBy |
methoxyamine
|
| gptkbp:involvedIn |
base excision repair
|
| gptkbp:locale |
gptkb:nucleus
mitochondria |
| gptkbp:mutationAssociatedWith |
genomic instability
increased sensitivity to DNA damaging agents |
| gptkbp:requires |
genome stability
|
| gptkbp:structure |
monomer
|
| gptkbp:substrate |
abasic DNA sites
|
| gptkbp:usedIn |
biotechnology research
|
| gptkbp:bfsParent |
gptkb:BER
|
| gptkbp:bfsLayer |
6
|