Anaphase-Promoting Complex

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:APC
gptkbp:catalyzes	ubiquitination of target proteins
gptkbp:co-activator	gptkb:CDC20 gptkb:CDH1
gptkbp:discoveredBy	1995
gptkbp:foundIn	eukaryotic cells
gptkbp:function	gptkb:ubiquitin_ligase regulation of cell cycle
gptkbp:GO_term	GO:0005680
https://www.w3.org/2000/01/rdf-schema#label	Anaphase-Promoting Complex
gptkbp:inhibitedBy	gptkb:BubR1 gptkb:Emi1 gptkb:Mad2
gptkbp:involves	cell division proteolysis ubiquitin-dependent protein catabolic process
gptkbp:locatedIn	gptkb:nucleus
gptkbp:pathway	cell cycle mitotic metaphase/anaphase transition
gptkbp:PDB	4UI9 5G3N
gptkbp:regulates	phosphorylation mitosis anaphase onset co-activators exit from mitosis
gptkbp:requires	chromosome segregation mitotic exit
gptkbp:species	gptkb:Mus_musculus gptkb:Saccharomyces_cerevisiae gptkb:Homo_sapiens
gptkbp:subunit	gptkb:APC1 gptkb:APC10 gptkb:APC2 gptkb:APC3 gptkb:APC4 gptkb:APC5 gptkb:APC6 gptkb:APC7 gptkb:APC8 gptkb:APC9 gptkb:CDC20 gptkb:CDH1
gptkbp:target	gptkb:cyclin_B gptkb:securin
gptkbp:UniProtID	Q9UJX2
gptkbp:bfsParent	gptkb:APS
gptkbp:bfsLayer	5