|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:B2AR
gptkb:beta-2_adrenoceptor
gptkb:beta-2_adrenergic_receptor
|
|
gptkbp:associatedWith
|
asthma
heart failure
obesity
hypertension
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Lefkowitz
|
|
gptkbp:encodes
|
Beta-2 adrenergic receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000169252
154
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
heart
liver
vascular smooth muscle
|
|
gptkbp:fullName
|
gptkb:adrenoceptor_beta_2,_surface
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
mediates effects of epinephrine and norepinephrine
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:Arg16Gly
gptkb:Gln27Glu
gptkb:Thr164Ile
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:286
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ADRB2
|
|
gptkbp:length
|
413 amino acids
|
|
gptkbp:locatedOnChromosome
|
5q31-q32
|
|
gptkbp:memberOf
|
gptkb:G_protein-coupled_receptor
gptkb:adrenergic_receptor_family
|
|
gptkbp:OMIM
|
109690
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Adrb2
|
|
gptkbp:PDB
|
gptkb:2RH1
gptkb:4LDE
gptkb:4LET
gptkb:4LEU
gptkb:4LEV
gptkb:4LEW
gptkb:4LEX
gptkb:4LEY
gptkb:4LEZ
3NY8
4LDL
4LDO
4LDQ
4LDR
4LDS
4LDT
4LDV
4LDW
4LDX
4LDY
4LDZ
4LE0
4LE1
4LE2
4LE3
4LE4
4LE5
4LE6
4LE7
4LE8
4LE9
4LEA
4LEB
4LEC
4LED
4LEE
4LEF
4LEG
4LEH
4LEI
4LEJ
4LEK
4LEL
4LEM
4LEN
4LEO
4LEP
4LEQ
4LER
4LES
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:targetOfDrug
|
beta-blockers
beta-agonists
|
|
gptkbp:type
|
activates adenylate cyclase
increases cAMP
|
|
gptkbp:UniProtID
|
gptkb:P07550
|
|
gptkbp:bfsParent
|
gptkb:CHEMBL137
gptkb:CHEMBL402
gptkb:CHEMBL1257
gptkb:beta-2_adrenergic_receptor
|
|
gptkbp:bfsLayer
|
7
|