|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ADRB2
Beta-2 adrenoceptor
|
|
gptkbp:associatedWith
|
asthma
chronic obstructive pulmonary disease
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:drugClass
|
adrenergic receptor
|
|
gptkbp:EC_number
|
7.6.2.1
|
|
gptkbp:enemyOf
|
gptkb:salbutamol
propranolol
terbutaline
butoxamine
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000169252
154
|
|
gptkbp:family
|
rhodopsin-like GPCR
|
|
gptkbp:fullName
|
Beta-2 adrenergic receptor
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
mediates effects of epinephrine and norepinephrine
|
|
gptkbp:gene
|
gptkb:ADRB2
|
|
gptkbp:GO
|
GO:0004930
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B2AR
|
|
gptkbp:length
|
413 amino acids
|
|
gptkbp:ligand
|
norepinephrine
epinephrine
|
|
gptkbp:locatedOnChromosome
|
5q31-q32
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:OMIM
|
109690
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus Adrb2
Rattus norvegicus Adrb2
|
|
gptkbp:PDB
|
gptkb:2RH1
|
|
gptkbp:phosphorylates
|
Ser355
Ser356
Thr360
|
|
gptkbp:RefSeq
|
NM_000024
|
|
gptkbp:regulates
|
internalization
desensitization by phosphorylation
downregulation
|
|
gptkbp:secondMessenger
|
gptkb:cAMP
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:skeletal_muscle
heart
liver
uterus
vascular smooth muscle
|
|
gptkbp:type
|
activates adenylate cyclase
|
|
gptkbp:UniProtID
|
gptkb:P07550
|
|
gptkbp:bfsParent
|
gptkb:ADRB2
|
|
gptkbp:bfsLayer
|
8
|