adrenoceptor beta 2, surface

URI: https://gptkb.org/entity/adrenoceptor_beta_2,_surface
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:beta-2_adrenergic_receptor
gptkbp:associatedWith asthma
heart failure
chronic obstructive pulmonary disease
gptkbp:discoveredBy gptkb:Robert_Lefkowitz
gptkbp:expressedIn gptkb:skeletal_muscle
liver
smooth muscle
lung tissue
gptkbp:family gptkb:adrenergic_receptor_family
gptkbp:function activates adenylate cyclase via Gs protein
binds epinephrine and norepinephrine
gptkbp:gene gptkb:ADRB2
gptkbp:GO GO:0004930
gptkbp:HGNC_ID gptkb:HGNC:286
https://www.w3.org/2000/01/rdf-schema#label adrenoceptor beta 2, surface
gptkbp:internalizedBy beta-arrestin
gptkbp:length 413
gptkbp:locatedOnChromosome 5q31-q32
gptkbp:modulatedBy beta blockers
antagonists
agonists
inverse agonists
partial agonists
gptkbp:molecularWeight 46 kDa
gptkbp:OMIM 109690
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:2RH1
gptkbp:phosphorylates gptkb:protein_kinase_A
G protein-coupled receptor kinases
gptkbp:recipient gptkb:G_protein-coupled_receptor
gptkbp:role glycogenolysis
vasodilation
smooth muscle relaxation
bronchodilation
gptkbp:species gptkb:Homo_sapiens
gptkbp:structureType 7 transmembrane domains
gptkbp:subfamily beta-adrenergic receptor subfamily
gptkbp:targetOfDrug gptkb:formoterol
gptkb:salmeterol
gptkb:albuterol
gptkb:isoproterenol
terbutaline
gptkbp:type gptkb:cAMP_pathway
gptkbp:UniProtID gptkb:P07550
gptkbp:bfsParent gptkb:ADRB2
gptkbp:bfsLayer 8