|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:ADRB2
gptkb:beta-2_adrenergic_receptor
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Lefkowitz
|
|
gptkbp:discoveredIn
|
1967
|
|
gptkbp:drugClass
|
adrenergic receptor
|
|
gptkbp:encodedBy
|
gptkb:ADRB2_gene
|
|
gptkbp:enemyOf
|
gptkb:formoterol
gptkb:salbutamol
propranolol
terbutaline
ICI 118,551
butoxamine
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
heart
liver
uterus
smooth muscle
bronchi
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
activates adenylate cyclase
increases cAMP
binds epinephrine
binds norepinephrine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
beta-2 adrenoceptor
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q31-q32
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:medicalUse
|
asthma treatment
COPD treatment
tocolysis
|
|
gptkbp:OMIM
|
109690
|
|
gptkbp:pathway
|
Gs protein pathway
|
|
gptkbp:PDB
|
gptkb:2RH1
|
|
gptkbp:regulates
|
desensitization by phosphorylation
internalization upon agonist binding
|
|
gptkbp:relatedTo
|
gptkb:beta-1_adrenoceptor
beta-3 adrenoceptor
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:UniProtID
|
gptkb:P07550
|
|
gptkbp:bfsParent
|
gptkb:ADRB2
gptkb:human_beta-2_adrenergic_receptor
|
|
gptkbp:bfsLayer
|
8
|